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Rodney R. Miles, MD, PhD
Medical Director: Hematopathology
Professor, University of Utah School of Medicine
Specialties
Non-Hodgkin lymphoma
Pediatric hematologic malignancies
Education
Medical Degree—University of Nebraska Medical Center
Doctorate Degree—Cell Biology, University of Nebraska Medical Center
Residency—Pathology, University of Utah School of Medicine
Fellowship—Hematopathology, University of Michigan
Certification/Affiliations
American Board of Pathology (Anatomic and Clinical Pathology, Hematology)
Research Interests
Biological subtypes of adult and pediatric non-Hodgkin lymphomas
Lymphoblastic leukemia and lymphoma
Awards
2015 Warren G. Sanger Award for Translational Lymphoma Research, 5th International Symposium on Childhood, Adolescent, and Young Adult Non-Hodgkin’s Lymphoma, Varese, Italy.
Recent Publications
Teachey DT, et al. Children's Oncology Group Trial AALL1231: a phase III clinical trial testing bortezomib in newly diagnosed T-cell acute lymphoblastic leukemia and lymphoma . J Clin Oncol . 2022;40(19):2106–18.
Underdown MJ, et al. Importance of clinical correlation in the diagnosis of pediatric B-cell lymphomas . Pediatr Blood Cancer . 2022;69(3):e29527.
Li P, et al. A clinical, histopathological, and molecular study of two cases of VEXAS syndrome without a definitive myeloid neoplasm . Blood Adv . 2022;6(2):405–9.
Burke GAA, et al. Dose-adjusted etoposide, doxorubicin, and cyclophosphamide with vincristine and prednisone plus rituximab therapy in children and adolescents with primary mediastinal B-cell lymphoma: a multicenter phase II trial . J Clin Oncol . 2021;39(33):3716–24.
Goldman S, et al. A dose substitution of anthracycline intensity with dose-dense rituximab in children and adolescents with good-risk mature B-cell lymphoma . Leukemia . 2021;35(10):2994–7.
Mangum DS, et al. Association of combined focal 22q11.22 deletion and IKZF1 alterations with outcomes in childhood acute lymphoblastic leukemia . JAMA Oncol . 2021;7(10):1521–8.
Xu X, et al. Genomic and clinical characterization of early T-cell precursor lymphoblastic lymphoma . Blood Ad v. 2021;5(14):2890–900.
Viola D, et al. Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting . Leukemia . 2021;35(1):189-200.
Hayashi RJ, et al. Successful outcomes of newly diagnosed T lymphoblastic lymphoma: results from Children's Oncology Group AALL0434 . J Clin Oncol . 2020;38(26):3062–70.
Minard-Colin V, et al. Rituximab for high-risk, mature B-cell non-Hodgkin's lymphoma in children . N Engl J Med . 2020;382(23):2207–19.
Radhakrishnan SV, et al. CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide . Nat Commun . 2020;11(1):798.
Atanackovic D, et al. In vivo vaccination effect in multiple myeloma patients treated with the monoclonal antibody isatuxima b. Leukemia . 2020;34(1):317–21.
Pearson ADJ, et al. ACCELERATE and European medicine agency paediatric strategy forum for medicinal product development for mature b-cell malignancies in children . Euro J Cancer . 2019 Mar;110:74–85.
Patel AB, Miles RR, Deininger MW. Lysozyme nephropathy in chronic myelomonocytic leukemia . Clin Case Rep . 2019 May 10;7(6):1263–4.
Jafek JL, et al. Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia . Exp Hematol. 2019 Aug;76:38–48.
Galardy PJ, et al. Lymphoma diagnostics: getting more from less . Jun;185(6):1136–41.
Chu Y, et al. Ibrutinib significantly inhibited Bruton’s thyrosine kinase (BTK) phosphorylation, in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model . 2018 Oct 11;8(1):e1512455.
Chisholm KM, et al. IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children’s Oncology Group trials . Pediatr Blood Cancer . 2019 Aug;66(8):
Borga C, et al. Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis . 2019 Feb;33 (2):333–7.
Zabriskie MS, et al. A novel AGGF1-PDGFRb fusion in pediatric T-cell acute lymphoblastic leukemia . Haematologica . 2018 Feb;103(2):e87–91.
Merzianu M, et al. Trends in bone marrow sampling and core biopsy specimen adequacy in the United States and Canada: a multicenter study . Am J Clin Pathol . 2018 Oct 1;150 (5):393–405.
Elkeeb D, et al. Ominous cutaneous presentation of acute myeloid leukemia without peripheral blood involvement upon initial presentation and relapse: case report and literature review . Eur J Dermatol. 2018 Dec 1;28(6): 809–17.
Tharkar-Promod S, et al. HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia . 2018 Jan;32(1):49–60.