Reference Interval:
| Test Number
| Components
| Reference Interval
| | | Neuronal Antibody IgG, Immunoblot Anti-Hu
| Negative
| | | Neuronal Antibody IgG, Immunoblot Anti-Ri
| Negative
| | | Neuronal Antibody IgG, Immunoblot Anti-Yo
| Negative
| | | Neuronal Antibody IgG, Immunoblot Amphiphysin
| Negative
|
|
| Interpretive Data: |
Anti-Hu (antineuronal nuclear antibody, type I) is associated with small-cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and fallopian tube and breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer.
The presence of one or more of these antibodies supports the clinical diagnosis of paraneoplastic syndrome and leads to a focused search for underlying neoplasm. These markers aid in the discrimination between true paraneoplastic disorders and other inflammatory disorders of the nervous system.
Amphiphysin antibodies are present in about 5% of patients with stiff person syndrome and variably in other paraneoplastic neurological syndrome (PNS) cases. Amphiphysin antibodies are mostly associated with small cell lung cancer (SCLC) and breast tumors.
See Compliance Statement D: www.aruplab.com/CS
|
| CPT Code(s): |
83516
|
|
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