ARUP's Laboratory Test Directory

Human Papillomavirus (HPV) DNA Probe, High-Risk Surepath™ (AutoCyte) : 0060744

Mnemonic: SP HPV-HI

Ordering Recommendation: Order to detect high-risk HPV types in cytology specimens collected in SurePath fluid.
Methodology: Qualitative Nucleic Acid Probe
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Patient Prep: Females should avoid high concentrations of antifungal cream, contraceptive jelly, or douche at time of collection.

Collect: Cervical Brush in SurePath™ liquid-based Pap test media.

Specimen Preparation: Place each specimen in an individually sealed bag. (Min: 2 mL)

Storage/Transport Temperature: Refrigerated.

Remarks: Specimen source required.

Unacceptable Conditions: Specimens in any transport media other than indicated above
For specimens in ThinPrep® Test transport media refer to ARUP test code 0060750. For cervical brush specimens in Digene specimen transport media, refer to ARUP test code 0065999.

Stability (collection to initiation of testing): Ambient: 2 weeks; Refrigerated: 4 weeks; Frozen: Unacceptable
Interpretive Data: Test Information:
The performance characteristics of HPV testing using the SurePath sample medium were determined by ARUP Laboratories in a validation study. The FDA has not approved the SurePath sample medium for HPV testing. Specimens collected in SurePath sample medium may produce false-negative results under certain conditions, e.g., when specimens exceed stability requirements. For HPV results using an FDA-approved test, laboratories should collect and transport specimens according to the instructions of FDA-approved kits (e.g., ThinPrep medium or HPV Digene collection kits).

This test detects the high-risk HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68 associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur. Results should be correlated with cytologic and histologic findings. Sensitivity may be affected by cellularity of specimen.

This test is intended for medical purposes only and is not valid for the evaluation of suspected sexual abuse or for other forensic purposes.

HPV testing should not be used for screening or management of atypical squamous cells of undetermined significance (ASCUS) in women under age 21.





See Compliance Statement B: www.aruplab.com/CS
CPT Code(s): 87621
Cross References: Condyloma (Human Papillomavirus (HPV) DNA Probe, High Risk Surepath® (AutoCyte)) , Genital Warts (Human Papillomavirus (HPV) DNA Probe, High Risk Surepath® (AutoCyte))