ARUP's Laboratory Test Directory

Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene) : 0065999

Mnemonic: HPV-HI

Ordering Recommendation: Order to detect high-risk HPV in cervical specimens collected with the Digene collection kit.
Methodology: Qualitative Nucleic Acid Probe
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Patient Prep: Females should avoid high concentrations of antifungal cream, contraceptive jelly, or douche at time of collection.

Collect: Cervical brush in HPV Digene Collection Kit (ARUP supply #12578). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.

Specimen Preparation: Place each specimen in an individually sealed bag. (Min: 1 mL)

Storage/Transport Temperature: Room temperature. Also acceptable: Refrigerated.

Remarks: Specimen source required.

Unacceptable Conditions: Specimens in any transport media other than indicated above.
For specimens in ThinPrep® Pap Test transport media, refer to test code 0060750; for specimens in SurePath® Pap specimen transport media, refer to test code 0060744.

Stability (collection to initiation of testing): Ambient: 2 weeks; Refrigerated: 3 weeks; Frozen: 3 months
Reference Interval:
Negative
 
Test Number Components Reference Interval
 Human Papillomavirus (HPV) DNA Probe, High Risk Only  Negative

Interpretive Data: This test detects the high-risk HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur. Results should be correlated with cytologic and histologic findings.  Sensitivity may be affected by cellularity of specimen.

This test is intended for medical purposes only and is not valid for the evaluation of suspected sexual abuse or for other forensic purposes.

HPV testing should not be used for screening or management of atypical squamous cells of undetermined significance (ASCUS) in women under age 21.
Note: A negative result does not rule out the presence of an HPV genotype absent from the test panel, a low level infection, or specimen sampling error. 
CPT Code(s): 87621
Cross References: Condyloma (Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene)), Genital Warts (Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene)), HPV High-Risk (Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene)), Hybrid Capture (Human Papillomavirus (HPV) DNA Probe, High Risk, Cervical Brush (Digene))