ARUP's Laboratory Test Directory

Oligoclonal Band Profile : 0080440

Mnemonic: OLIGO

Ordering Recommendation: Preferred CSF test for the workup of suspected multiple sclerosis. Detects IgG oligoclonal bands in CSF and calculates the CSF IgG index.
Methodology: Qualitative Isoelectric Focusing/Electrophoresis/Nephelometry
Performed: Mon, Wed, Fri
Reported: Between 1 and 4 days
Specimen Required: Collect: CSF AND serum separator tube. Serum specimen should be drawn within 48 hours of CSF collection.

Specimen Preparation: Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF. (Min: 0.7 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Remarks: Specimens must be assayed together for interpretation.

Stability (collection to initiation of testing): Ambient: 8 hours; Refrigerated: 1 week; Frozen: 1 year
Reference Interval:
 
Test Number Components Reference Interval
0050350Immunoglobulin G  
 
0- 30 days: 611-1542 mg/dL             
1 month: 241-870 mg/dL                         
2 months: 198-577 mg/dL           
3 months: 169-558 mg/dL                   
4 months: 188-536 mg/dL                         
5 months: 165-781 mg/dL                         
6 months: 206-676 mg/dL                           
7-8 months: 208-868 mg/dL                        		9-11 months: 282-1026 mg/dL
1 year: 331-1164 mg/dL
2 years: 407-1009 mg/dL
3 years: 423-1090 mg/dL
4 years: 444-1187 mg/dL
5-7 years: 608-1229 mg/dL
8-9 years: 584-1509 mg/dL
10 years and older: 768-1632 mg/dL
0050670Immunoglobulin G, CSF 0-6.0 mg/dL
0050200Albumin, CSF 0-35 mg/dL
 Albumin Index0.0-9.0
 CSF IgG/Albumin Ratio0.09-0.25
 IgG Index 0.28-0.66
 CSF Oligoclonal Bands Negative
 Interpretation By report
 CSF IgG Synthesis Rate Less than or equal to 8.0 mg/d
0050671Albumin by Nephelometry 3500-5200 mg/dL
 Oligoclonal Bands, CSF/Serum,  Number 0 - 1 Bands
 
Note: A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.
CPT Code(s): 83916; 82784 x2; 82040; 82042
Cross References: MS Panel (Oligoclonal Band Profile), MS Profile (Oligoclonal Band Profile), Multiple Sclerosis Panel (Oligoclonal Band Profile), Multiple Sclerosis Panel without Myelin Basic Protein (Oligoclonal Band Profile), Multiple Sclerosis Profile (Oligoclonal Band Profile)