ARUP's Laboratory Test Directory

Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine : 0081352
[ image for: Patient History for Mucopolysaccharides (MPS) Testing]
Patient History for Mucopolysaccharides (MPS) Testing
[ image for: Additional Technical Information]
Additional Technical Information


Mnemonic: MPS SCREEN

Ordering Recommendation: Use to evaluate symptomatic patients for mucopolysaccharidoses (MPS). To monitor glycosaminoglycans (GAGs) in patients previously diagnosed with MPS, refer to Mucopolysaccharides, Quantitative, Urine (0081357).
Methodology: Electrophoresis/Spectrophotometry
Performed: Tue
Reported: 4-14 days
Specimen Required: Patient Prep: Morning void preferred.

Collect: Urine.

Specimen Preparation: Freeze specimen immediately. Transport 20 mL urine. (Min: 10 mL)

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Specimens containing preservatives.

Stability (collection to initiation of testing): Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Reference Interval:
Test Number Components Reference Interval
Mucopolysaccharides, Electrophoresis Pattern By report
0081357Mucopolysaccharides, Quantitative, Urine 0-5 months: 14.6-47.8 mg/mmol creatinine
6-11 months: 3.7-35.5 mg/mmol creatinine
1-2 years: 5.4-30.8 mg/mmol creatinine
3-6 years: 5.2-16.7 mg/mmol creatinine
7-13 years: 2.4-10.2 mg/mmol creatinine
14 years or older: 0.0-7.1 mg/mmol creatinine

Interpretive Data: Mucopolysaccharides (Glycosaminoglycans) include: Keratan Sulfate, Heparan Sulfate, Dermatan Sulfate, and Chondroitin Sulfates 4 and 6. The excretion of Heparan Sulfate is variable. A normal mucopolysaccharides screen does not exclude Sanfilippo Syndrome (Mucopolysaccharidosis Type III).

See Compliance Statement B: www.aruplab.com/CS
CPT Code(s): 83866; 83864
Cross References: GAG(s) (Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine), Glycosaminoglycans (Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine), Hunter (Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine), Hurler (Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine), Maroteaux-Lamy (Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine), Morquio (Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine), Sanfilippo (Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine), Scheie (Mucopolysaccharides Screen - Electrophoresis & Quantitation, Urine)