ARUP's Laboratory Test Directory

Imipramine and Desipramine, Serum or Plasma : 0090157

Mnemonic: DESIP/IMIP

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed: Sun-Sat
Reported: 1-3 days
Specimen Required: Patient Prep: Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect: Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA).

Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Stability (collection to initiation of testing): After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
Reference Interval:
Effective February 19, 2013
 
Therapeutic Range Total (imipramine and desipramine): 150-300 ng/mL
Toxic Level Greater than 500 ng/mL

Interpretive Data: Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.
Note: Report includes individual values for imipramine, desipramine, and total.
CPT Code(s): 80174; 80160
Cross References: Antideprin (Imipramine and Desipramine), Deprenil (Imipramine and Desipramine), Deprimin (Imipramine and Desipramine), Deprinol (Imipramine and Desipramine), Desipramine/Imipramine (Imipramine and Desipramine), Eupramin (Imipramine and Desipramine), Imipramil (Imipramine and Desipramine), Imipramine and Metabolite (Imipramine and Desipramine), Imipramine/Desipramine Fractionation (Imipramine and Desipramine), Impril (Imipramine and Desipramine), Irmin (Imipramine and Desipramine), Janimine (Imipramine and Desipramine), Melepramin (Imipramine and Desipramine), Novo-Parmine (Imipramine and Desipramine), Presamine (Imipramine and Desipramine), Surplix (Imipramine and Desipramine), Tofranil (Imipramine and Desipramine), Tripramine (Imipramine and Desipramine)