ARUP's Laboratory Test Directory

Mycophenolic Acid : 0090213

Mnemonic: MPA

Methodology: High Performance Liquid Chromatography
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Patient Prep: Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect: Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Stability (collection to initiation of testing): After separation from cells: Ambient: 6 weeks; Refrigerated: 6 weeks; Frozen: 11 months
Reference Interval:
Effective February 19, 2013
 
Therapeutic Range Not well established
Toxic Level Greater than 25.0 µg/mL

Interpretive Data: A proposed therapeutic range is 1.0-3.5 µg/mL for a 2 g/day dose. A 3 g/day dose may have plasma concentrations up to 5.0 µg/mL. Trough concentrations between 2.0 and 4.0 µg/mL have been suggested to maximize efficacy and minimize adverse effects. Adverse effects of toxicity include abdominal pain, peripheral edema, cardiac abnormalities, hypertension and electrolyte disturbances.
CPT Code(s): 80299
Cross References: Cellcept™ (Mycophenolic Acid) , CellCept™ MPA (Mycophenolic Acid) , Mofetil Ester (Mycophenolic Acid), Mycophenolate (Mycophenolic Acid), Mycophenolate Mofetil (Mycophenolic Acid), Myfortic™ (Mycophenolic Acid) , Prodrug (Mycophenolic Acid)