#ExistRefRange>Reports include age appropriate reference intervals and interpretation.
|Absolute CD4 (Helper T-cells)
|Absolute CD8 (Suppressor T-cells)
|Absolute CD3 (Total T-cells)
|CD4: CD8 ratio
#ExistInterpData>In this test, the CD4 cells are Helper T-cells because they express both CD3 and CD4. The CD8 cells are Suppressor T-cells because they express both CD3 and CD8. Helper T-cell levels are a criterion for categorizing HIV-related clinical conditions by the CDC's classification system for HIV infection. The measurement of Helper T-cell levels has been used to establish decision points for initiating P. jiroveci prophylaxis, antiviral therapy and to monitor the efficacy of treatment. The Public Health Service (PHS) has recommended that Helper T-cell levels be monitored every three to six months in all HIV-infected persons.
The performance characteristics of this test were determined by ARUP Laboratories, Inc.
See Compliance Statement B: www.aruplab.com/CS
||This assay is designed for enumerating the absolute cell counts of lymphocyte subsets in lysed whole blood. Whole blood is added to fluorochrome-labeled antibodies that bind specifically to cell surface antigens on lymphocytes. After incubation, lysing and fixation, absolute counts are enumerated utilizing an internal quantitation standard. Additional CBC data is not required.
During HIV infection, antiviral therapy is often initiated when the absolute CD4 count drops below 500 cells/µL. When the absolute CD4 count drops below 200 cells/µL, therapeutic prophylaxis against PCP and other opportunistic infections may be initiated. When the absolute CD4 count drops below 100 cells/µL, prophylaxis against Mycobacterium avium complex is recommended.
For longitudinal studies involving serial monitoring, specimen collections should be performed at the same time of day.
||Absolute CD4 and CD8 (Lymphocyte Subset Panel 3-T-Cell Subsets (CD4 & CD8), Absolute Count), Lymphocyte Subset CD4 and CD8 (Lymphocyte Subset Panel 3-T-Cell Subsets (CD4 & CD8), Absolute Count)