ARUP's Laboratory Test Directory

Zonisamide : 0097908

Mnemonic: ZONI

Methodology: Quantitative Enzyme Multiplied Immunoassay Technique
Performed: Mon-Fri
Reported: 1-4 days
Specimen Required: Patient Prep: Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect: Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA).

Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated

Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Stability (collection to initiation of testing): After separation from cells: Ambient: 6 weeks; Refrigerated: 6 weeks; Frozen: 6 weeks
Reference Interval:
Effective February 19, 2013
 
Therapeutic Range Not well established
Toxic Level Greater than 80 µg/mL

Interpretive Data: The proposed therapeutic range for seizure control is 10-40 µg/mL. Toxic concentrations may cause coma, seizures and cardiac abnormalities. Pharmacokinetics varies widely, particularly with co-medications and/or compromised renal function.
CPT Code(s): 80299
Cross References: Excegran (Zonisamide), Zonegran (Zonisamide)