ARUP's Laboratory Test Directory

Clomipramine and Metabolite, Serum or Plasma : 0099336

Mnemonic: CLOMIP

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed: Sun-Sat
Reported: 1-3 days
Specimen Required: Patient Prep: Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect: Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Stability (collection to initiation of testing): After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
Reference Interval:
Effective February 19, 2013
 
Therapeutic Range Total (clomipramine and norclomipramine): 220-500 ng/mL
Toxic Level Greater than 900 ng/mL

Interpretive Data: The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive compulsive disorder is not well established. Toxic concentrations may cause anticholinergic effects, CNS depression, cardiac abnormalities, seizures and hypotension.
CPT Code(s): 80299
Cross References: Anafranil (Clomipramine & Metabolite), Desmethylclomipramine (Clomipramine & Metabolite), Norclomipramine (Clomipramine & Metabolite)