ARUP's Laboratory Test Directory

Crohn Disease Prognostic Panel : 2001613

Mnemonic: CROHN PAN

Ordering Recommendation: May aid in prognostication of confirmed Crohn disease (CD). May also be useful in the diagnosis of CD.
Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Tue
Reported: 1-8 days
Specimen Required: Collect: Serum separator tube (SST).

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma, other body fluids, grossly icteric, heat-inactivated, grossly hemolyzed, severely lipemic, or contaminated specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
(avoid repeated freeze/thaw cycles)
Reference Interval:
Available Separately Components Reference Interval
No Saccharomyces cerevisiae Antibody (gASCA), IgG 0-44 Units: Negative
45-50 Units: Equivocal
51 Units or greater: Positive
No Laminaribioside Carbohydrate Antibody (ALCA), IgG 0-54 Units: Negative
55-60 Units: Equivocal
61 Units or greater: Positive
No Mannobioside Carbohydrate Antibody (AMCA), IgG 0-89 Units: Negative
90-100 Units: Equivocal
101 Units or greater: Positive
No Chitobioside Carbohydrate Antibody (ACCA), IgA 0-79 Units: Negative
80-90 Units: Equivocal
91 Units or greater: Positive

Interpretive Data: If only one of the four markers in the Crohn Disease Prognostic Panel is positive, clinical specificity is at least 85 percent. If all four markers are negative and inflammatory bowel disease (IBD) is suspected, testing for ANCA by IFA is recommended to confirm or exclude the possibility of ulcerative colitis (UC).

See Compliance Statement A: www.aruplab.com/CS
CPT Code(s): 86671; 83516 x3
Cross References: Glycan Antibodies (Crohn Disease Prognostic Panel), IBD Prognostic Panel (Crohn Disease Prognostic Panel), IBDX (Crohn Disease Prognostic Panel), Inflammatory Bowel Disease Prognostic Panel (Crohn Disease Prognostic Panel)