ARUP's Laboratory Test Directory

Voriconazole, Quantitation by LC-MS/MS : 2001737
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Additional Technical Information
  


Mnemonic: VORICON AF

Methodology: Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed: Tue, Thu, Sat
Reported: 1-6 days
Specimen Required: Patient Prep: Specimens collected just before or within 15 minutes of the next dose represent the TROUGH levels. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection or 90 minutes after oral intake represent the PEAK level. Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect: Plain red, lavender (EDTA), or green (sodium or lithium heparin).

Specimen Preparation: Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Separator tubes. Hemolyzed or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months

Reference Interval:
Effective February 19, 2013
Therapeutic Range (trough) 1.0-6.0 µg/mL
Toxic Level Greater than 6.0 µg/mL

Interpretive Data: Toxic concentrations may cause nausea, vomiting, peripheral edema and elevated serum liver enzymes.

See Compliance Statement B: www.aruplab.com/CS
CPT Code(s): 80299
Cross References: Vfend (Voriconazole, Quantitation by LC-MS/MS)