ARUP's Laboratory Test Directory

ST2, Soluble : 2002270
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Additional Technical Information
  


Mnemonic: ST2

Ordering Recommendation: B-Type Natriuretic Peptide (0030191) or proBrain Natriuretic Peptide, NT (0050083) are preferred tests for diagnosis, prognosis, and management of acute and chronic heart failure. ST2 aids in prognostication in patients with acute and chronic heart failure.
Methodology: Quantitative Enzyme Immunoassay
Performed: Tue
Reported: 1-8 days
Specimen Required: Collect: Serum separator tube, plain red, lavender (EDTA) or pink (K2EDTA).

Specimen Preparation: Allow serum specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transport 1 mL serum or plasma. (Min: 0.2 mL) Avoid repeated freeze/thaws.)

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Specimen types other than serum or plasma. Specimens stored or transported at room temperature for more than 48 hours.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 10 days; Frozen: 1 year
Reference Interval:
 
Males 10.4-52.1 ng/mL
Females 8.4-33.6 ng/mL

Interpretive Data: The ST2 test, an enzyme-linked immunosorbent assay, quantifies soluble ST2 in serum or plasma. ST2 is a member of the interleukin-1 (IL-1) receptor family and is secreted by cardiac muscle cells under conditions of mechanical stress. In individuals with acute myocardial infarction, an increased concentration of soluble ST2 is associated with an increased risk of mortality or heart failure. In individuals with heart failure, an increased concentration of soluble ST2 is strongly associated with the severity of disease and is a strong predictive indicator of 1-year mortality that is independent but additive to that of NT-proBNP.
CPT Code(s): 83520