ARUP's Laboratory Test Directory

Factor XIII, Qualitative, with Reflex to Factor XIII 1:1 Mix : 2002819
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Additional Technical Information
  


Mnemonic: FACTOR 13

Methodology: Qualitative Solubility
Performed: Sun-Sat
Reported: 2-3 days
Specimen Required: Collect: Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation: Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Remarks:

Unacceptable Conditions: Serum. Non-frozen or hemolyzed specimens.

Stability (collection to initiation of testing): Ambient: 4 hours; Refrigerated: 8 hours; Frozen: 2 weeks
Reference Interval:
 
Test Number Components Reference Interval
 Factor XIII, Qualitative No Lysis within 24 hours
 Factor XIII, 1:1 Mix Not Applicable

Note: This is a qualitative screening test; clot lysis only occurs in specimens with severe factor XIII deficiency (less than 1 percent of normal activity). Severe deficiency may be inherited or acquired (typically due to a factor XIII antibody). If clot lysis occurs in the initial testing, then Factor XIII 1:1 Mix will be added where the test is repeated using a 1:1 mix of patient plasma and pooled normal plasma to distinguish between FXIII deficiency and a FXIII inhibitor. Additional charges apply.

False-positive results (lysis) can be caused by heparin (therapy with unfractionated or low molecular weight heparin or contamination from a line), decreased or abnormal fibrinogen, increased fibrinolysis (inherited or acquired fibrinolytic disorders), fibrinolytic drugs, or other factors that affect clot structure or stability.
CPT Code(s): 85291; if reflexed, add additional 85291
Cross References: Clot Solubility