ARUP's Laboratory Test Directory

Interferon Beta Neutralizing Antibody with Reflex to Titer : 2003390

Mnemonic: IFNB NEU R

Ordering Recommendation: Aids in management of individuals treated with interferon beta.
Methodology: Cell Culture/Chemiluminescent Immunoassay
Performed: Thu
Reported: 1-15 days
Specimen Required: Patient Prep: Collect specimens before Interferon beta treatment, or more than 48 hours following the most recent dose. Patient should not be on steroid therapy in excess of 10 mg prednisolone (or equivalent) daily. High endogenous levels of Interferon beta, alpha, or gamma may interfere with this assay.

Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Contaminated, hemolyzed, icteric, or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
Available Separately Components Reference Interval
Interferon Beta Screen Negative
Interferon Beta Titer Less than 20: Negative
20 to 99: Moderate levels of neutralizing antibodies present
100 or greater: High levels of neutralizing antibodies present

Interpretive Data: A titer of 20 to 99 suggests moderate levels of neutralizing antibodies present. A titer of 100 or greater suggests high levels of neutralizing antibodies present. Either case warrants continued patient monitoring. The titer is reported as the reciprocal of the dilution of patient serum that reduces the interferon activity by 10 fold.

See Compliance Statement B: www.aruplab.com/CS
Note: If Interferon Beta Neutralizing Antibody screen result is positive, then Interferon Beta Neutralizing Antibody titer will be added. 

This test is performed pursuant to an agreement with Biomonitor.
CPT Code(s): 86352; if reflexed, add 86352
Cross References: iLite (Interferon Beta Neutralizing Antibody with Reflex to Titer), Interferon-Beta (Interferon Beta Neutralizing Antibody with Reflex to Titer), Multiple Sclerosis (Interferon Beta Neutralizing Antibody with Reflex to Titer), NAb (Interferon Beta Neutralizing Antibody with Reflex to Titer), NabFeron (Interferon Beta Neutralizing Antibody with Reflex to Titer), Neutralization (Interferon Beta Neutralizing Antibody with Reflex to Titer)