ARUP's Laboratory Test Directory

BCR-ABL1, Major (p210), Quantitative : 2005017
[ image for: Time Sensitive]
Time Sensitive
[ image for: Additional Technical Information]
Additional Technical Information


Mnemonic: BCR MAJ

Ordering Recommendation: This quantitative test is appropriate for diagnosis and therapeutic monitoring. The BCR-ABL1 major (p210) fusion forms are present in almost all cases of CML and in a small subset of cases of ALL.
Methodology: Quantitative Reverse Transcription Polymerase Chain Reaction
Performed: RNA isolation: Sun-Sat
Assay: Varies
Reported: 5-7 days
Specimen Required: Collect: Lavender (EDTA) or bone marrow (EDTA).

Specimen Preparation: Transport 5 mL whole blood or 3 mL bone marrow. (Min: 1 mL whole blood or 1 mL bone marrow) Specimens must be received within 48 hours of collection due to lability of RNA.

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Serum or plasma. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed specimens. Frozen or clotted specimens.

Stability (collection to initiation of testing): Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable
Interpretive Data: Refer to report.

See Compliance Statement D: www.aruplab.com/CS
Note: This test does not detect the rare BCR-ABL1 micro (p230) fusion form.

For the p190 fusion form (minor breakpoint), order BCR-ABL1, Minor (p190), Quantitative (ARUP test code 2005016).
CPT Code(s): 81206, G0452