ARUP's Laboratory Test Directory

Chromatin Antibody, IgG : 2005287
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Additional Technical Information
  


Mnemonic: CHROMATIN

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Wed
Reported: 1-8 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, icteric, or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval:
Effective July 18, 2011
 
19 Units or less Negative
20-60 Units Moderate Positive
61 Units or greater Strong Positive

Interpretive Data: The presence of anti-chromatin antibodies may be useful in the diagnosis of systemic lupus erythematosus (SLE) or drug-induced lupus (DIL) and have been reported to be predictive of lupus nephritis, especially when antibody levels are high.
CPT Code(s): 83516
Cross References: Anti-Chromatin (Chromatin Antibody, IgG), Anti-DNP (Chromatin Antibody, IgG), Anti-Nucleosome (Chromatin Antibody, IgG), Antichromatin (Chromatin Antibody, IgG), Antinucleosome (Chromatin Antibody, IgG), H2A-H2B-H3-H4 (Chromatin Antibody, IgG), LE-Cell Factor (Chromatin Antibody, IgG), Nucleosome (Chromatin Antibody, IgG)