Reference Interval:
1.33 Units or less
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| Interpretive Data: |
A value of greater than 1.33 Units suggests the presence of basophil stimulating antibodies (or other serum factors).
See Compliance Statement B: www.aruplab.com/CS
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| Note: |
1) Chronic urticaria (CU) is a common and complex dermatological condition that is suspected when patients experience persistent hives for over 6 weeks. No published evidence of an exogenous allergen as the cause of this disorder exists. About 45 percent of cases have autoantibodies directed against either basophil or mast cell-associated IgE or the high affinity IgE-Fc receptor (Fc epsilon R1 alpha) (Clin Exp Allergy 2009; 39: 777-87).
2) The presence of histamine releasing factors (including but not limited to IgE and Fc epsilon R1 alpha-specific autoantibodies) in the patient serum can be indirectly determined by evaluating basophil/mast cell activation status using histamine release assays, autologous serum-skin test, and flow cytometric measurement of the basophil and mast-cell specific marker CD203c. Serum from CU patients can activate donor basophils, which induces histamine release and CD203c upregulation (J Allergy Clin Immunol 2006; 117: 1430-4).
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| CPT Code(s): |
88184; 88185 x2 each additional marker
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Cross References: |
Anti IgE Receptor Ab (Urticaria-Induced Basophil Activation), Chronic Urticaria (Urticaria-Induced Basophil Activation) |
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