#ExistRefRange>High-Risk HPV: Negative
#ExistInterpData>Women with atypical squamous cells of undetermined significance (ASC-US) should be managed using a program of either repeat cervical cytology testing, immediate colposcopy, or DNA testing for high-risk types of Human Papillomavirus (HPV). Testing for HPV DNA is the preferred approach when liquid-based cytology is used for screening. All women who test positive for high-risk HPV DNA should be referred for colposcopic evaluation. Women with ASC-US who test negative for high-risk HPV DNA can be followed up with repeat cytologic testing at 12 months (2001 ASCCP Guidelines -JAMA 2002; 287:2120-2129):
A positive high-risk HPV test result indicates that the patient may be infected with one or more of the following HPV genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68, which are associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur. Results should be correlated with cytologic/histologic findings.
||A negative result does not rule out the presence of an HPV genotype absent for the test panel, a low level infection, or specimen sampling error.
||CPT codes vary based on testing performed If reflexed, add 87621
||Pap Test (Cytology, ThinPrep® Pap with Reflex to Human Papillomavirus (HPV) DNA Probe, High Risk)
, ThinPrep® Reflex to HPV (Cytology, ThinPrep® Pap with Reflex to Human Papillomavirus, High Risk)