Reference Interval:
High-risk HPV: Negative
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| Interpretive Data: |
Women with atypical squamous cells of undetermined significance (ASC-US) should be managed using a program of either repeat cervical cytology testing, immediate colposcopy, or DNA testing for high-risk types of Human Papillomavirus (HPV). Testing for HPV DNA is the preferred approach when liquid-based cytology is used for screening. All women who test positive for high-risk HPV DNA should be referred for colposcopic evaluation. Women with ASC-US who test negative for high-risk HPV DNA can be followed up with repeat cytologic testing at 12 months (2001 ASCCP Guidelines -JAMA 2002; 287:2120-2129)
A positive high risk HPV test result indicates that the patient may be infected with one or more of the following HPV genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68; which are associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur. Results should be correlated with cytologic/histologic findings.
The performance characteristics of this test were determined by ARUP Laboratories, Inc.
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| Note: |
A negative result does not rule out the presence of an HPV genotype absent from the test panel, a low level infection, or specimen sampling error.
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| CPT Code(s): |
CPT Codes vary based on testing performed. If reflexed, add 87621
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Cross References: |
Pap Test (Cytology, SurePath™ Liquid-Based Pap Test (AutoCyte PREP™ System) with Reflex to Human Papillomavirus (HPV) DNA Probe, High Risk)
, SurePath™ Pap Test (Cytology, SurePath™ Liquid-Based Pap Test (AutoCyte PREP™ System) with Reflex to Human Papillomavirus (HPV) DNA Probe, High Risk)
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