Hemostasis Factor Deficiencies

Coagulation factor testing is performed to assess if a person has enough coagulation activity to control the blood clotting process. Low coagulation factor activity is associated with reduced clot formation and excess bleeding. High coagulation factor activity can be associated with too much clot formation (thrombosis) and blockade in the circulatory system (thromboembolism).

One or more coagulation factor activity tests may be ordered to evaluate the function of specific factors. If the activity testing shows reduced activity, then an antigen test may be ordered as a follow-up.

Test Code Tests Ordering Recommendations
30007 Factor II, Activity (Prothrombin) Evaluate for possible factor II deficiency.
30075 Factor V, Activity Evaluate for possible factor V deficiency.
30080 Factor VII, Activity Evaluate for possible factor VII deficiency.
30095 Factor VIII, Activity Order to diagnose hemophilia A, acquired factor VIII deficiency, or as part of a diagnostic workup for von Willebrand disease. Not recommended when screening for thrombophilia.
30026 Factor VIII, Activity with Reflex to Bethesda Quantitative, Factor VIII Order to diagnose factor VIII deficiency, detect factor VIII inhibitors, and monitor factor VIII replacement therapy.
30100 Factor IX, Activity Order to diagnose factor IX deficiency (hemophilia B) and monitor factor IX replacement therapy.
30032 Factor IX, Activity with Reflex to Bethesda Quantitative, Factor IX Order to diagnose factor IX deficiency, detect factor IX inhibitors, and monitor factor IX replacement therapy.
30105 Factor X, Activity Evaluate possible factor X deficiency.
30110 Factor XI, Activity Order to diagnose factor XI deficiency (hemophilia C).
30115 Factor XII, Activity Evaluate the cause of an isolated prolonged PTT in a patient who is not currently bleeding.
2002819 Factor XIII, Qualitative, with Reflex to Factor XIII 1:1 Mix Most useful for acquired or severe FXIII deficiency testing. Abnormal results should be confirmed with quantitative testing (Factor XIII Activity 2006182).
20061802 Factor XIII Activity First-line test to diagnose FXIII deficiency. Appropriate for evaluation of patients with a bleeding disorder present with normal PT, PTT, and platelet count test results. Use for monitoring FXIII therapy and for confirming abnormalities detected on FXIII qualitative assay.
Molecular
2001747 Hemophilia A (F8) Sequencing Identify causal F8 variant in individuals with established mild to moderate hemophilia A and determine carrier status for those with a family history of mild to moderate hemophilia A. For severe hemophilia A, Hemophilia A (F8) 2 Inversions with Reflex to Sequencing and Reflex to Deletion/Duplication (2001614) is recommended.
2001614 Hemophilia A (F8) 2 Inversions with Reflex to Sequencing and Reflex to Deletion/Duplication Detect causal F8 variant in individuals with established severe hemophilia A and determine carrier status in at-risk females with severely affected male relatives. For mild to moderate hemophilia A, Hemophilia A (F8) sequencing (2001747) is preferred.
2001578 Hemophilia B (F9) Sequencing Acceptable test to confirm diagnosis or determine carrier status for F9 gene variants.

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