von Willebrands

von Willebrand disease (VWD) is the most common congenital bleeding disorder. VWD may result from either a quantitative (types 1 and 3) or qualitative (type 2) abnormality of von Willebrand factor (VWF). This disorder affects both males and females and is more common in caucasians. It may also occur less frequently as an acquired disorder (acquired von Willebrand syndrome: AVWS). While population screening is not recommended, clinical and laboratory evaluation of individuals with bleeding symptoms, a history of bleeding, or conditions associated with increased bleeding risk should be screened.


Von Willebrand Testing
0030284 von Willebrand Modified Panel Order in conjunction with Factor VIII Activity (0030095) for the workup of suspected von Willebrand disease.
0030285 von Willebrand Factor Antigen Order in conjunction with von Willebrand Factor Activity (Ristocetin Cofactor) (0030250) and Factor VIII Activity (0030095) as part of initial workup of suspected von Willebrand disease.
0030250 von Willebrand Factor Activity (Ristocetin Cofactor) Order in conjunction with von Willebrand Factor Antigen (0030285) and Factor VIII Activity (0030095) as part of initial orkup of suspected von Willebrand disease.
0030125 von Willebrand Panel Recommended panel for the initial workup of suspected von Willebrand disease.
0030002 von Willebrand Multimeric Panel Not recommended for initial screening except in suspected cases of acquired von Willebrand disease (vWD) or high suspicion of vWD. Preferred initial test is von Willebrand Panel with Reflex to von Willebrand Multimeric Analysis (2003387).
0092281 von WIllebrand Factor Multimers Order to subclassify established von WIllebrand disease.
2003387 von Willebrand Panel with Reflex to von Willebrand Multimeric Analysis Recommended reflex panel to diagnose and subclassify suspected von Willebrand disease.
Molecular
2005476 von Willebrand Disease, Platelet Type (GP1BA) 4 Mutations Molecular testing to distinguish von Willebrand disease (vWD) type 2B from pseudo (platelet-type) vWD.
2005486 von Willebrand Disease, Type 2B (VWF) Sequencing Molecular testing to confirm a phenotypic diagnosis of von Willebrand disease type 2B and to distinguish from pseudo (platelet-type) vWD.
2005490 von Willebrand Disease, Type 2M (VWF) Sequencing Molecular testing to confirm a phenotypic diagnosis of von Willebrand disease type 2M.
2005494 von Willebrand Disease, Type 2N (VWF) Sequencing Molecular testing to distinguish von Willebrand disease type 2N from hemophilia A.
2005480 von Willebrand Disease, Type 2A (VWF) Sequencing Exon 28 with Reflex to 9 Exons Molecular testing to confirm a phenotypic diagnosis of von Willebrand disease type 2A.