Cutoff Values for Quantitative Confirmation

Quantitative confirmation testing is performed by chromatography mass spectrometry (LC-MS/MS or GC-MS). Below are the cutoff values used in each of these tests. Cutoff values of the urine High-resolution Hybrid Test Panel are also shown for comparison.

When the "Reflex to Quantitative Confirmation" tests are ordered, we automatically confirm the drug(s) found positive in the screen. Note that confirmation testing will not occur if the screen is negative.

Drugs Tested by Mass Spectrometry Urine Quantitative Confirmation Serum/Plasma Quantitative Confirmation High-Resolution Hybrid Test Panel Qualitative
Amphetamine (AMP) 200 ng/mL 20 ng/mL 100 ng/mL
Barbiturates 50 ng/mL 50 ng/mL 200 ng/mL
Benzodiazepines 20 ng/mL 20 ng/mL 20 - 50 ng/mL
Buprenorphine (& metabolite) 2 ng/mL 2 ng/mL 5 ng/mL
Carisoprodol (& metabolite) 100 ng/mL 2-4 ug/mL 100 ng/mL
Cocaine (metabolite) 50 ng/mL 20 ng/mL 150 ng/mL
Codeine 5 ng/mL 2 ng/mL 40 ng/mL
Fentanyl (& metabolite) 1 ng/mL 0.1 ng/mL 2 ng/mL
Hydrocodone 5 ng/mL 2 ng/mL 40 ng/mL
Marijuana (THC) 5 ng/mL 5 ng/mL 20 ng/mL
MDMA (ecstasy) 200 ng/mL 5 ng/mL 200 ng/mL
Meperidine (& metabolite) 2 ng/mL 2 ng/mL 50 ng/mL
Methadone (& metabolite) 10 ng/mL 10 ng/mL 150 ng/mL
Methylphenidate (& metabolite) 10 ng/mL 1 ng/mL 100 ng/mL
Opiates 20 ng/mL 2 ng/mL 10 - 40 ng/mL
Oxycodone 20 ng/mL 2 ng/mL 40 ng/mL
Phencyclidine 10 ng/mL 10 ng/mL 25 ng/mL
Propoxyphene 10 ng/mL 10 ng/mL 300 ng/mL
Tapentadol 50 ng/mL 50 ng/mL 100 ng/mL
Tramadol 50 ng/mL 50 ng/mL 200 ng/mL
Tricyclic antidepressants 100 - 200 ng/mL 10 -25 ng/mL Not analyzed
Ethanol or ethyl glucuronide Varies Varies 500 ng/mL