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Serotonin, Serum
Ordering Recommendation
Preferred serotonin test when diagnosing carcinoid tumors is Serotonin, Whole Blood (0080395).
New York DOH Approval Status
Specimen Required
Abstain from medications for 72 hours prior to collection.
Serum Separator Tube(SST).
Separate from cells within 1 hour of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Frozen. Separate specimens must be submitted when multiple tests are ordered.
Specimens other than serum. Non-frozen specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 24 hours; Frozen: 1 month
Methodology
Quantitative High Performance Liquid Chromatography (HPLC)
Performed
Mon, Wed, Thu, Fri, Sat
Reported
1-5 days
Reference Interval
50-220 ng/mL
Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Note
Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.
In general, EDTA whole blood (as compared to serum) preserved with ascorbic acid will give values most representative of blood concentrations. Most (95 percent) of blood serotonin is found in platelets. Refer to Serotonin, Whole Blood (ARUP test code 0080395).
Hotline History
Hotline History
CPT Codes
84260
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0080397 | Serotonin, Serum | 27057-9 |
Aliases
- 5-HT
- 5-Hydroxy Tryptamine
- 5-Hydroxytryptamine
