ARUP at ASH 2023

Workshop

Friday, December 8, 2023
4:18–4:59 p.m.
Room 29 (San Diego Convention Center)

How Scientific Advances Impact Clinical Predictive Models and Recommendations

Symposia: Scientific Workshop on Germline Predisposition to Hematopoietic Malignancies and Bone Marrow Failure

Somatic Pathogenic UBA1 Mutations Predispose Male Patients to Myeloid Neoplasms (with Q&A)

Margaret Williams, MD

Poster Session

 

Saturday, December 9, 2023
9:30–11:00 a.m.
Ballroom 20AB (San Diego Convention Center)

634. Myeloproliferative Syndromes: Clinical and Epidemiological: Rare Myeloproliferative Neoplasms: Unveiling Promising Pathways and Novel Therapies

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10:15 a.m.

76. Elenestinib, An Investigational, Next Generation KIT D816V Inhibitor, Reduces Mast Cell Burden, Improves Symptoms, and Has a Favorable Safety Profile in Patients With Indolent Systemic Mastocytosis: Analysis of the Harbor Trial

Tsewang Tashi, MD; Olivier Hermine, MD, PhD; Mariana Castells, MD, PhD; Mar Guilarte, MD, PhD; Vito Sabato, MD, PhD; Marcus Maurer, MD; Jens Panse, MD; Ivan Alvarez-Twose, MD, PhD; Renata Cabral, MD; Robert Bird, MBBS; Stéphane Barete, MD, PhD; Laurence Bouillet, MD, PhD; Maud Hermans, MD, PhD; Paul Van Daele, MD, PhD; David González-De-Olano, MD, PhD; Elizabeth A. Griffiths, MD; Joseph Jurcic, MD; Ingunn Dybedal, MD, PhD; Gandhi Laurent Damaj, MD, PhD; Philippe Schafhausen; Chiara Elena, MD; Tse-Chieh Teh, MD, PhD; Pankit Vachhani, MD; Caroline Labe, BA; Saranya Venugopal, MS, MPharm; Kevin He, PhD; Javier Muñoz-González, PhD; Ben Lampson, MD, PhD; Robyn Scherber, MD; Prithviraj Bose, MD; Clive Grattan, MD; Thanai Pongdee, MD; Tracy I. George, MD; Cristina Bulai Livideanu, MD

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10:30 a.m.

77. Initial Results From Summit: An Ongoing, 3-Part, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Study of Bezuclastinib in Adult Patients With Nonadvanced Systemic Mastocytosis (nonAdvSM)

Prithviraj Bose, MD; Stephen T. Oh, MD, PhD; Brian Modena, MD; Anthony M. Hunter, MD; Cem Akin, MD, PhD; Mariana Castells, MD, PhD; Michael Manning, MD; Richard Herrscher; Frank Siebenhaar, MD;  Daniel J. DeAngelo, MD, PhD; Tracy I. George, MD; Benjamin Exter, PharmD; Jenna Zhang, PhD; Amanda Pilla; Hina Jolin, PharmD; Rachael Easton, MD, PhD; Lindsay A.M. Rein, MD

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Poster Session

Saturday, December 9, 2023
5:30–7:30 p.m.
Halls G-H (San Diego Convention Center)

642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster I

1913. Prediction of Time-to-First Treatment (TTFT) in Favorable-Risk Chronic Lymphocytic Leukemia (CLL) Patients Using a Novel Stratification Through Transcriptome Risk Scoring

Boyu Hu, MD; Brian Avery, PhD; Rosalie Griffin, PhD; Julie Feusier, PhD; Ahmad Halwani, MD; Justin Williams, MPH; Brandt Jones, BS; Michael Madsen, MStat; Deborah M. Stephens, DO; Nicola J. Camp, PhD

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Poster Session

Sunday, December 10, 2023
4:30–6:00 p.m.
Pacific Ballroom Salons 24-26 (Marriott Marquis San Diego Marina)

613. Acute Myeloid Leukemias: Clinical and Epidemiological: Real World Outcomes and Treatment Approaches

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5:30 p.m.

593. Treatment Patterns and Outcomes of Patients With Acute Myeloid Leukemia (AML) From 2013 to 2022: A Connect^® Myeloid Registry Study

David L. Grinblatt, MD; Gail J. Roboz, MD; Daniel A. Pollyea, MD, MS; Mikkael A. Sekeres, MD, MS; Bart L. Scott, MD; Karen Seiter, MD; Amer M. Zeidan, MBBS, MHS; Jay L. Patel, MD; Guillermo Garcia-Manero, MD; Rami S. Komrokji, MD; Michael R. Savona, MD; Irene S. Degutis, PharmD; Pavel Kiselev, PhD; Edward Yu, ScD; Willem Heydendael, PhD; Ying Qiu, PhD; Sara Vergara, MD; Ali McBride, PharmD; Harry P. Erba, MD, PhD

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Poster Session

Monday, December 11, 2023
6:00–8:00 p.m.
Halls G-H (San Diego Convention Center)

634. Myeloproliferative Syndromes: Clinical and Epidemiological: Poster III

4551. Deep and Durable Cytogenetic and Molecular Responses With Pemigatinib in Myeloid/Lymphoid Neoplasms With Fibroblast Growth Factor Receptor 1 Rearrangement: The Fight-203 Study

Andreas Reiter, MD; Jean-Jacques Kiladjian, MD, PhD; Jay L. Patel, MD; William Shomali, MD; Alessandro Rambaldi, MD; Srdan Verstovsek, MD, PhD; Stephen Oh, MD, PhD; Kensuke Usuki, MD, PhD; Claire N. Harrison; Ellen K. Ritchie, MD; Luke P. Akard, MD; Juan Carlos Hernandez Boluda, MD, PhD; Françoise Huguet, MD; Natalia Oliveira, MBA; Huiling Zhen, PhD; Tracy I. George, MD; Philomena Colucci, DO, MS; Aidan Gilmartin; Jason Gotlib, MD; Alessandro M. Vannucchi, MD

4567. Safety and Efficacy of Bezuclastinib (CGT9486), A Novel, Highly Selective, Potent KIT D816V, Tyrosine Kinase Inhibitor, In Patients With Advanced Systemic Mastocytosis (AdvSM): Results From Part 1 of the Phase 2 Apex Trial

Pankit Vachhani, MD; Tsewang Tashi, MD; Gary J. Schiller, MD; Stephanie Lee, MD, MSc; Miguel Piris Villaespesa, MD, PhD; Helena Pomares, MD, PhD; Cristina Bulai Livideanu, MD; Jonathan Lambert, PhD, BSc, BMBS, FRCP, FRCPath; Anthony M. Hunter, MD; Tracy I. George, MD; Cristina Papayannidis, MD; Khalid Shoumariyeh, MD; Rita Petroro; Jenna Zhang, PhD; Amanda Pilla; Hina Jolin; Rachael Easton; Vinod Pullarkat, MD

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General Session

Tuesday, December 12, 2023
9:00—10:30 a.m.

LBA-6. ERG Is a New Predisposition Gene for Bone Marrow Failure and Hematological Malignancy

Hamish S. Scott, PhD, BSc, Jiarna Zerella, BSc, Claire Homan, Peer Arts, BSc, PhD, Steve Lin, Sam J. Spinelli, Milena Babic, Peter J. Brautigan, Lynda Truong, Luis Arriola-Martinez, Parvathy Venugopal, PhD, MSc, BSc, Simone K. Feurstein, MD, Lise Larcher, Flore Sicre De Fontbrune, Serwet Demirdas, Sonja De Munnik, Hélène Poirel, Benedicte Brichard, Sara Dobbins, Pim Mutsaers, MD, Desiree S. DeMille, Josue Flores-Daboub, Michael W. Drazer, MD, PhD, Alison Crawford, Julie McCarrier, Donald G. Basel, Kerry Phillips, Nicola K. Poplawski, MD, FRACP, Graeme Birdsey, Daniela Pirri, Pia Ostergaard, Annet Simons, Lucy Godley, MD, PhD, David M. Ross, MBBS, PhD, FRACP, FRCPA, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA, Jean Soulier, MD, Anna Brown, PhD, BSc, Catherine Carmichael, PhD, and Christopher N. Hahn, PhD