Qinwen Mao, MD, PhD

Professor, University of Utah School of Medicine

Specialties

• Neuropathology

Education

• Medical Degree—Fourth Military Medical University, China
• Master of Science—Histology, Fourth Military Medical University, China
• Doctorate Degree—Physiology, Fourth Military Medical University, China
• Residency—Anatomic Pathology, University of Texas Southwestern Medical School
• Clinical Fellowship—Neuropathology, University of Texas Southwestern Medical School

Certification/Affiliations

• Diplomate of the American Board of Pathology: Anatomic Pathology and Neuropathology

Research Interests

• Pathogenesis and management of Alzheimer’s disease; frontotemporal lobar degeneration
• Chronic traumatic encephalopathy
• Biomarker development for dementia

Awards

• Presidential Symposium & Presentation of the Top Abstracts, the American Society of Gene & Cell Therapy Annual Meeting, Minneapolis, Minnesota (2004)
• Travel Award, American Association of Neuropathologists Annual Meeting, San Diego, California (2008)
• A.D. Sobel–American Society for Investigative Pathology Education Fund Scholar for Outstanding Research in Experimental Pathology (2008)
• Outstanding Teacher, Science in Medicine Lecture, Northwestern University Feinberg School of Medicine, Chicago, Illinois (2014-2020)
• Travel Award, American Association of Neuropathologists Annual Meeting, Louisville, Kentucky (mentor) (2018)
• Eisenberg Scholar, Northwestern University (2018)
• Woman and Diversity Award, American Association of Neuropathologists Annual Meeting (mentor) (2020)
• Hirano Award for the Best Paper on Neurodegenerative Diseases, American Association of Neuropathologists Annual Meeting (mentor) (2020)

Recent Publications

Original Investigations

• Huang QQ, Doyle R, Chen SY, et al. Critical role of synovial tissue-resident macrophage niche in joint homeostasis and suppression of chronic inflammation. Sci Adv. 2021;7(2):eabd0515.
• Walker JM, Richardson TE, Farrell K, et al. Early selective vulnerability of the ca2 hippocampal subfield in primary age-related tauopathy. J Neuropathol Exp Neurol. 2021;80(2):102-111.
• Kam KL, Appin CL, Mao Q, et al. Is next-generation sequencing alone sufficient to reliably diagnose gliomas? J Neuropathol Exp Neurol. 2020;79(7):763-766.
• Gefen T, Mao Q, Kohler M, et al. Primary progressive aphasia has a unique signature distinct from dementia of the Alzheimer's type and behavioral variant frontotemporal dementia regardless of pathology. J Neuropathol Exp Neurol. 2020;79(12):1379-1381.
• Du C, Wu Y, Ju T, et al. The luciferase reporter system of the MMP12 endogenous promoter for investigating transcriptional regulation of the human MMP12 gene. Electronic Journal of Biotechnology. 2020; 43(1):55-61.
• Jara JH, Gautam M, Kocak N, et al. MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology. J Neuroinflammation. 2019;16(1):196.
• Zhang J, Zhao J, Mao Q, et al. A simple, efficient and economical method for isolating and culturing human umbilical cord bloodderived mesenchymal stromal cells. Mol Med Rep. 2019;20(6):5257-5264.
• Zhu J, Wang N, Li X, et al. suppression of progranulin expression leads to formation of intranuclear TDP-43 inclusions in vitro: a cell model of frontotemporal lobar degeneration. J Neuropathol Exp Neurol. 2019;78(12):1124-1129.
• Li Y, Li S, Li Y, et al. Generation of a novel HEK293 luciferase reporter cell line by CRISPR/Cas9-mediated site-specific integration in the genome to explore the transcriptional regulation of the PGRN gene. Bioengineered. 2019;10(1):98-107.
• Mao Q, Zheng X, Gefen T, et al. FTLD-TDP with and without GRN mutations cause different patterns of CA1 pathology. J Neuropathol Exp Neurol. 2019;78(9):844-853.
• Nishihira Y, Gefen T, Mao Q, et al. Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes. Acta Neuropathol. 2019;138(1):167-169.
• Rogalski E, Gefen T, Mao Q, et al. Cognitive trajectories and spectrum of neuropathology in SuperAgers: the first 10 cases. Hippocampus. 2019;29(5):458-467.
• Li Y, Wang D, Li Y, et al. A highly sensitive sandwich ELISA to detect CSF progranulin: a potential biomarker for CNS disorders. J Neuropathol Exp Neurol. 2019;78(5):406-415.
• Maniar KP, Arva N, Blanco LZ Jr, et al. Accreditation council for graduate medical education (ACGME) self-study for pathology: one institution's experience and lessons learned. Arch Pathol Lab Med. 2019;143(10):1271-1277.
• Shan L, Wang D, Mao Q, et al. Establishment of a DGKθ endogenous promoter luciferase reporter HepG2 cell line for studying the transcriptional regulation of DGKθ gene. Appl Biochem Biotechnol. 2019;187(4):1344-1355.
• Zhang D, Kim SSR, Kelly DF, et al. Somatostatin receptor ligand therapy-a novel therapy for neurocytoma. J Clin Endocrinol Metab. 2019;104(6):2395-2402.
• Hojat A, Wei B, Olson MG, et al. Procurement and storage of surgical biospecimens. Methods Mol Biol. 2019;1897:65-76.
• Chen H, Li Y, Du C, et al. Aptazyme-mediated direct modulation of post-transcriptional sgRNA level for conditional genome editing and gene expression. J Biotechnol. 2018;288:23-29.
• Li Z, Zhao J, Muhammad N, et al. Establishment of a HEK293 cell line by CRISPR/Cas9-mediated luciferase knock-in to study transcriptional regulation of the human SREBP1 gene. Biotechnol Lett. 2018;40(11-12):1495-1506.
• Zhang W, Zhao J, Li Y, et al. Establishing a dual knock-out cell line by lentivirus based combined CRISPR/Cas9 and Loxp/Cre system. Cytotechnology. 2018;70(6):1595-1605.
• Gefen T, Ahmadian SS, Mao Q, et al. Combined pathologies in FTLD-TDP types A and C. J Neuropathol Exp Neurol. 2018;77(5):405-412.
• Zhang J, Zhao J, Zheng X, et al. Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKtheta gene knockout. Mol Med Rep. 2018;17(2):2169-2176.
• Huang QQ,  Birkett R, Doyle R, et al. the role of macrophages in the response to tnf inhibition in experimental arthritis. J Immunol. 2018;200(1):130-138.
• Zhang W, Xiao D, Shan L, et al. Generation of apoptosis-resistant HEK293 cells with CRISPR/Cas mediated quadruple gene knockout for improved protein and virus production. Biotechnol Bioeng. 2017;114(11):2539-2549.
• Mao Q, Wang D, Li Y, et al. Disease and region specificity of granulin immunopositivities in alzheimer disease and frontotemporal lobar degeneration. J Neuropathol Exp Neurol. 2017;76(11):957-968.
• Li Y, Li Y, Ye M, et al. Biological function analysis of monoclonal antibodies against human granulins in vitro using U251 cells as a model. Protein Expr Purif. 2017;130:55-62.
• Kovacs GG, Xie SX, Lee EB, et al. Multisite assessment of aging-related Tau astrogliopathy (ARTAG). J Neuropathol Exp Neurol. 2017;76(7):605-619.
• Chen F, Li Y, Zhao J, et al. Domain-specific monoclonal antibodies against human rev-erbbeta. Appl Biochem Biotechnol. 2017;182(3):978-989.

Reviews and Case Reports

• Kam K L, Brooker SM, Mao Q, et al. Newly diagnosed enhancing lesions: Steroid initiation may impede diagnosis of lymphoma involving the central nervous system. J Clin Neurosci. 2020;81:61-64.
• McCord MR, Bigio EH, Kam KL, et al. Spinocerebellar ataxia type 3: a case report and literature review. J Neuropathol Exp Neurol. 2020;79(6):641-646.
• Apple AC, Mao Q, Bigio E, et al. Sleep talking and primary progressive aphasia: case study and autopsy findings in a patient with logopenic primary progressive aphasia and dementia with Lewy bodies. BMJ Case Rep. 2019;12(5):e228938.
• Muhammad N, Mao Q, Xia H. CAR T-cells for cancer therapy. Biotechnol Genet Eng Rev. 2017;33(2):190-226.
• Hakar M,  Chandler JP, Bigio EH, et al. Neuroendocrine carcinoma of the pineal parenchyma. The first reported case. J Clin Neurosci. 2017;35:68-70.