Qinwen Mao, MD, PhD

Professor, University of Utah School of Medicine

Specialties

• Neuropathology

Education

• Medical Degree—Fourth Military Medical University, China
• Master of Science—Histology, Fourth Military Medical University, China
• Doctorate—Physiology, Fourth Military Medical University, China
• Residency—Anatomic Pathology, University of Texas Southwestern Medical School
• Clinical Fellow—Neuropathology, University of Texas Southwestern Medical School

Certification/Affiliations

• Diplomate of the American Board of Pathology: Anatomic Pathology and Neuropathology

Research Interests

• Pathogenesis and management of Alzheimer’s disease; frontotemporal lobar degeneration
• Chronic traumatic encephalopathy
• Biomarker development for dementia

Awards

• Woman and Diversity Award, American Association of Neuropathologists Annual Meeting (mentor), 2020
• Hirano Award for the Best Paper on Neurodegenerative Diseases, American Association of Neuropathologists Annual Meeting (mentor), 2020
• Travel Award, American Association of Neuropathologists Annual Meeting, Louisville, Kentucky (mentor), 2018
• Eisenberg Scholar, Northwestern University, 2018
• Outstanding Teacher, Science in Medicine Lecture, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 2014-2020
• Travel Award, American Association of Neuropathologists Annual Meeting, San Diego, California, 2008
• A.D. Sobel–American Society for Investigative Pathology Education Fund Scholar for Outstanding Research in Experimental Pathology, 2008
• Presidential Symposium & Presentation of the Top Abstracts, the American Society of Gene & Cell Therapy Annual Meeting, Minneapolis, Minnesota, 2004

Recent Publications

• Robinson LJ, Goold E, Cannon DM, et al. A rare case of an adult primary intracranial sarcoma associated with a DICER1 mutation. J Neuropathol Exp Neurol. 2024;83(5):365-369.
• Wang J, Zhao X, Wang Q, et al. FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA. Cell Mol Life Sci. 2024;81(1):107.
• Kawles A, Keszycki R, Minogue G, et al. Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias. Acta Neuropathol Commun. 2024;12(1):31.
• Robinson LJ, Ferguson D, Walker C, et al. A rare case of fibromuscular dysplasia involving the cervicocephalic arterial tree highlighting the neuropathological findings. J Neuropathol Exp Neurol. 2024;83(3):209-213.
• Ravindra VM, Robinson L, Jensen H, et al. Morphological and ultrastructural investigation of the posterior atlanto-occipital membrane: Comparing children with Chiari malformation type I and controls. PLoS One. 2024;19(1):e0296260.
• Robinson LJ, Goold E, Potter S, et al. A pleomorphic xanthoastrocytoma highlighting the morphological heterogeneity of this uncommon tumor. J Neuropathol Exp Neurol. 2023;83(1):61-64.
• Scholz SW, Moroz BE, Saez-Atienzar S, et al. Association of cardiovascular disease management drugs with Lewy body dementia: a case-control study. Brain Commun. 2023;6(1):fcad346.
• Zhu J, Yang J, Wen H, et al. Expression and functional analysis of fam76b in zebrafish. Fish Shellfish Immunol. 2023;142L109161.
• Robinson LJ, Sudarshan D, Goold E, et al. A novel, pathogenic COL4A1 missense variant involving thrombotic microangiopathic leukoencephalopathy in a neonate. J Neuropathol Exp Neurol. 2023;82(10):880-883.
• Minogue G, Kawles A, Zouridakis A, et al. Distinct patterns of hippocampal pathology in Alzheimer's disease with TDP-43. Ann Neurol. 2023;94(6):1036-1047.
• Zhang W, Xiao D, Mao Q, et al. Role of neuroinflammation in neurodegeneration development. Signal Transduct Target Ther. 2023;8(1):267.
• Galbraith K, Vasudevaraja V, Serrano J, et al. Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines for clinical testing. Neurooncol Adv. 2023;5(1):vdad076.
• Kaivola K, Chia R, Ding J, et al. Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias. Cell Genom. 2023;3(6):100316.
• Huang QQ, Hang Y, Doyle R, et al. Mechanisms regulating the loss of Tregs in HUPO mice that develop spontaneous inflammatory arthritis. iScience. 2023;26(5):106734.
• Wang J, Gao H, Xie Y, et al. Lycium barbarum polysaccharide alleviates dextran sodium sulfate-induced inflammatory bowel disease by regulating M1/M2 macrophage polarization via the STAT1 and STAT6 pathways. Front Pharmacol. 2023;14:1044576.
• Nelson PT, Lee EB, Cykowski MD, et al. LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathol. 2023;145(2):159-173.
• Multz RA, Spencer C, Matos A, et al. What every neuropathologist needs to know: condensed protocol work-up for clinical dementia syndromes. J Neuropathol Exp Neurol. 2023;82(2):103-109.
• Lilek J, Ajroud K, Feldman AZ, et al. Accumulation of pTau231 at the postsynaptic density in early Alzheimer's disease. J Alzheimers Dis. 2023;92(1):241-260.
• Wu D, Wang J, Chang Y, et al. Rutaecarpin reduces lipids by DGKθ-dependent activation of PPARα. Obesity (Silver Spring). 2022;30(12):2424-2439.
• Zhang D, Yong W, Movassaghi M, et al. Whole exome sequencing identifies PHF14 mutations in neurocytoma and predicts responsivity to the PDGFR inhibitor sunitinib. Biomedicines. 2022;10(11):2842.
• Nassif C, Kawles A, Ayala I, et al. Integrity of neuronal size in the entorhinal cortex is a biologic substrate of exceptional cognitive aging. J Neurosci. 2022;42(45):8587-8594.
• McKenzie AT, Marx GA, Koenigsberg D, et al. Interpretable deep learning of myelin histopathology in age-related cognitive impairment. Acta Neuropathol Commun. 2022;10(1):131.
• Farrell K, Iida MA, Cherry JD, et al. Differential vulnerability of hippocampal subfields in primary age-related tauopathy and chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2022;81(10):781-789.
• Zheng X, Mi T, Wang R, et al. Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury. Glia. 2022;70(7):1317-1336.
• Stanley NE, Robinson LJ, Mao Q. A novel, heterozygous BSCL2 variant in association with early-onset epileptic encephalopathy. J Neuropathol Exp Neurol. 2022;81:377-380.
• Sukumaran M, Mao Q, Cantrell DR. Holohemispheric prostate carcinoma dural metastasis mimicking subdural hematoma: case report and review of the literature. J Neurol Surg Rep. 2022;83(1):e23-e28.
• Muhammad N, Wang R, Li W, et al. A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy. Mol Ther Oncolytics. 2022;24:729-741.
• Farrell K, Kim S, Han N, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022;143(1):33-53.
• Kaivola K, Shah Z, Chia R, et al. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain. 2022;145(5):1757-1762.
• Kawles A, Nishihira Y, Feldman A, et al. Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C. Brain. 2022;145(3):1069-1078.
• Zhang J, Chen H, Chen C, et al. Systemic administration of mesenchymal stem cells loaded with a novel oncolytic adenovirus carrying IL-24/endostatin enhances glioma therapy. Cancer Lett. 2021;509:26-38.
• Gefen T, Kawles A, Makowski-Woidan B, et al. Paucity of entorhinal cortex pathology of the Alzheimer's type in SuperAgers with superior memory performance. Cereb Cortex. 2021;31(7):3177-3183.
• Chia R, Sabir MS, Bandres-Ciga S, et al. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet. 2021;53(3):294-303.
• Dewan R, Chia R, Ding J, et al. Pathogenic huntingtin repeat expansions in patients with frontotemporal dementia and amyotrophic lateral sclerosis. Neuron. 2021;109(3):448-460.e4.
• Walker JM, Richardson TE, Farrell K, et al. Early selective vulnerability of the CA2 hippocampal subfield in primary age-related tauopathy. J Neuropathol Exp Neurol. 2021;80(2):102-111.
• Huang QQ, Doyle R, Chen SY, et al. Critical role of synovial tissue-resident macrophage niche in joint homeostasis and suppression of chronic inflammation. Sci Adv.  2021;7(2):eabd0515.
• Gefen T, Mao Q, Kohler M, et al. Primary progressive aphasia has a unique signature distinct from dementia of the alzheimer's type and behavioral variant frontotemporal dementia regardless of pathology. J Neuropathol Exp Neurol. 2020;79(12):1379-1381.
• Kam KL, Appin CL, Mao Q,et al. is next-generation sequencing alone sufficient to reliably diagnose gliomas? J Neuropathol Exp Neurol. 2020;79(7):763-766.
• Du C, Wu Y, Ju Y, et al. The luciferase reporter system of the MMP12 endogenous promoter for investigating transcriptional regulation of the human MMP12 gene. Elec J Biotech. 2020;43:55-61.