Changhong Xing, MD, PhD

Assistant Professor (Clinical), University of Utah School of Medicine

Specialties

• Neuropathology

Education

• Medical Degree–Hebei Medical University, China
• Master of Medicine–Pathology, Peking University Health Science Center, China
• Doctorate Degree–Neurobiology, Tsinghua University, China
• Residency–Anatomic Pathology, University of Texas Southwestern Medical Center
• Fellowship–Neuropathology, University of Texas Southwestern Medical Center

Current/Past Roles

• Assistant Professor, Massachusetts General Hospital, Harvard Medical School
• Anatomic Pathologist, Beijing Chaoyang Hospital, Capital Medical University, China

Certification/Affiliations

• American Board of Pathology, Anatomic Pathology

Research Interests

• Basic and translational research of ischemic stroke
• Neuroimmune interactions
• Microglial phenotypic switch
• Help-me signaling in the neurovascular unit
• Vasculome in neurodegenerative diseases
• Immune microenvironment in brain tumors

Awards

• Travel Award, American Association of Neuropathologists Annual Meeting (2020)
• Janet Caldwell, MD, Memorial Fellowship Research Award, Department of Pathology, University of Texas Southwestern Medical Center (2023)

Recent Publications

• Li W, Mandeville ET, Durán-Laforet V, et al. Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. Nat Commun. 2022;13(1):7812.
• Xing C, et al. The brain vasculome: an integrative model for CNS function and disease. In: Galis ZS, ed. The Vasculome: From Many, One. Elsevier/Academic Press; 2022:427-440.
• Yu F,  Saand A, Xing C, et al. CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome. J Cereb Blood Flow Metab. 2021:41(10):2524-2533.
• Deng W, Mandeville E, Terasaki Y, et al. Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab. 2020;40(1_suppl):S34-S48.
• Takase H, Chou SH, Hamanaka G, et al. Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage. Neurology. 2020;94(12):e1281-1293.
• Deng W, Xing C, David R, et al. AmpliSeq transcriptome of laser captured neurons from Alzheimer brain: comparison of single cell versus neuron pools. Aging Dis. 2019;10(6):1146-1158.
• Du Y, Li W, Lin L, et al. Effects of lipocalin-2 on brain endothelial adhesion and permeability. PLoS One. 2019;14(7):e0218965.
• Guo S, Deng W, Xing C, et al. Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes. Neurobiol Dis. 2019;126:117-123.
• Zhao Q, Yu Z, Zhang F, et al. HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPARγ activity in vitro. J Neurochem. 2019;149(2):298-310.