Hemostasis/Thrombosis

ARUP offers routine and esoteric testing for bleeding and thrombotic disorders.

Our test menu and new test developments are guided by the clinical expertise of our medical directors and Research and Development (R&D) scientists. Our board-certified medical directors are available to answer questions regarding test results, discuss possible test interferences, and consult with fellow healthcare professionals on challenging or unusual cases.

Featured Tests

Lupus Anticoagulant Reflex Panel

ARUP is one of the only labs to offer a reflexive test panel that reduces the risk of false-positive and false-negative results by detecting and neutralizing common anticoagulant medications, including both direct oral anticoagulants (DOACs) and heparins.
ARUP’s panel returns results within 1–3 days.

Prolonged Clot Time Reflexive Profile

Use to evaluate prolonged clotting times to inform treatment of bleeding disorders, conduct presurgical evaluations, and guide blood product replacement.
Guided by ARUP medical directors, the diagnostic workup is performed on a single specimen set, which optimizes time to diagnosis and minimizes patient redraws.
Customized, expert interpretation by an ARUP medical director provides information about the clinical significance of any abnormalities identified and recommendations for follow-up testing.

Serotonin Release Assay (Heparin Dependent Platelet Antibody), Unfractionated Heparin

ARUP performs this gold standard test for the diagnosis of heparin-induced thrombocytopenia (HIT) in-house and returns results within 2–4 days.

ARUP Testing FAQs

Yes, anticoagulant medications have the potential to interfere with specialized coagulation testing. Please refer to the ARUP Consult Impacts of Common Anticoagulants on Coagulation Testing topic for additional information.

Yes, to produce valid results for hemostasis/thrombosis testing, including factor assays, specimen integrity is crucial and must be maintained. For additional guidance, please refer to the Hemostasis/Thrombosis Specimen Collection and Handling instructions.

Heparin-induced thrombocytopenia (HIT) is a clinicopathologic diagnosis that requires a combined evaluation of clinical examination and laboratory test results. It is recommended to use a clinical scoring system, such as the 4Ts system, to establish the need for diagnostic laboratory testing in HIT. For more information, refer to the ARUP Consult Heparin-Induced Thrombocytopenia topic.

Platelet Surface Glycoprotein Expression (PGE) by Flow Cytometry, Whole Blood (test code 2013070) is a sensitive assay that only requires a relatively small sample volume to diagnose Bernard-Soulier syndrome or Glanzmann thrombasthenia. This test allows for a longer specimen stability of 72 hours because it is not a functional assay. For additional information, refer to the test information in ARUP’s Laboratory Test Directory.