Human Papillomavirus (HPV) Testing Highlights

Human papillomavirus (HPV) is the most common sexually transmitted viral infection in the United States.

Most HPV infections are benign and resolve on their own, but persistent infection with any of the high-risk HPV genotypes increases a woman’s risk for developing cervical cancer. 

To assist in the detection and surveillance of HPV infections, ARUP offers multiple molecular screening and testing options based on current cervical cancer screening guidelines from the American College of Obstetricians and Gynecologists (ACOG), the American Society for Colposcopy and Cervical Pathology (ASCCP), the United States Preventive Services Task Force (USPSTF), and the American Cancer Society (ACS).  

Why Choose ARUP?

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Flexible Testing Options

Clinicians have the ability to order the testing indicated for individual patient populations.

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Cost Saving Opportunities

ARUP offers multiple HPV testing options at various price points.

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Reliable Results

ARUP’s screening tests detect 14 high-risk HPV genotypes in a single analysis, differentiates HPV16 and HPV18 from other high-risk types, and aligns reporting with current cervical cancer screening guidelines.

Additional Resources

Education

An Update on HPV Versus Non-HPV-Associated Endocervical Adenocarcinoma 
Video Lecture by Lesley C. Lomo, MD
Pathologist


Molecular HPV Testing Options

Test NameTest NumberTest UtilityResult TypeHPV Genotype Targets
Human Papillomavirus (HPV) High Risk Screen, by Transcription-Mediated Amplification (TMA), ThinPrep3016943Preferred screening method for HPV

Detected/Not Detected

Genotypes not differentiated

16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68


 

Human Papillomavirus (HPV) High Risk Screen by Transcription-Mediated Amplification (TMA), with Reflex to Genotypes 16 and 18/45, ThinPrep3016945

Detects HPV with reflex to additional genotype differentiation

 

 

Detected/Not Detected

If detected, high-risk genotypes HPV 16 and HPV 18/45 will be reported

Human Papillomavirus (HPV) Genotypes 16 and 18/45, by Transcription-Mediated Amplification (TMA), ThinPrep3016944

High-risk genotype differentiation

 

HPV genotype 16:  Detected/Not Detected

HPV genotype 18/45: Detected/Not Detected

16, 18/45
HPV Primary Screen by PCR with Reflex to Cytology
 
3016636Detects HPV with additional genotype 16 & 18 differentiation and reflex to cytology

HPV genotype 16: Detected/Not Detected

HPV genotype 18: Detected/Not Detected

HPV high risk target genotypes 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68): Detected/Not Detected

Cytology by report

16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68

 

Human Papillomavirus (HPV), High Risk with 16 and 18 Genotype by PCR, ThinPrep
 
2011940Detects HPV 16, HPV18 and HPV High-risk.

HPV genotype 16: Detected/Not Detected

HPV genotype 18: Detected/Not Detected

HPV high risk target genotypes (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68): Detected/Not Detected

Human Papillomavirus (HPV), High Risk with 16 and 18 Genotype by PCR, SurePath
 
2011933