Screening and Diagnosis

Tests used to screen for and diagnose diabetes mellitus (DM) include:

• Glucose, Plasma or Serum (0020024)
• Hemoglobin A1c (0070426)
  • Our testing uses capillary electrophoresis to separate different forms of hemoglobin, which allows for a direct measurement of HbA1c. This technology is less susceptible to interference from hemoglobin variants and modified forms of hemoglobin than other methods.
• Glucose Tolerance Test (0020542)
  • Glucose tolerance tests have a high sensitivity for diagnosis of prediabetes and diabetes.
• Glucose Screen, Pregnancy (0020047)

Etiology

Diabetes-related autoantibody testing can help to establish autoimmune etiology in individuals previously diagnosed with type 1 DM (T1DM) or to exclude a diagnosis of T1DM in adults who lack traditional risk factors.

Our single orderable tests allow you to tailor a testing combination most beneficial for your patient’s unique situation.

• The American Diabetes Association (ADA) recommends ordering at least two antibody tests to receive the best results and to aid in predicting clinical DM.¹
• For most cases, order Glutamic Acid Decarboxylase Antibody (2001771) in combination with one or more of the following:
  • Islet Antigen-2 (IA-2) Autoantibody, Serum (3001499)
  • Zinc Transporter 8 Antibody (2006196)
  • Islet Cell Cytoplasmic Antibody, IgG (0050138)
  • Insulin Antibody (0099228)

Molecular Analysis

ARUP offers one of the most comprehensive genetic testing panels on the market that includes 23 genes to identify patients with DM for whom genetic etiology is suspected.

1. MODY and Neonatal Diabetes Panel, Sequencing (3001593)

Additional associated tests offered by ARUP may be useful for glycemic control monitoring.

1. 1,5 Anhydroglucitol Quantitative, Serum or Plasma (0081335)
2. Fructosamine (0099012)